A Novel Coated Graphite Electrode for Potentiometric Determination of Pyrilamine Maleate in Pharmaceutical Compounds and Biological Fluids
نویسندگان
چکیده
A new pyrilamine coated graphite electrode (CGE) based on pyrilamine-tetraphenylborate ion-pair (Pyra-TPB) as electroactive material has been described. The sensor exhibited a linear response with a good Nernstian slope over a relatively wide range of concentration. The membrane film of the electrode made of 3% (w/w) ion-pair, 48.5% DBP (w/w) and 48.5% PVC (w/w). The sensor displays Nernstian response of 58.4±0.4 mV/decade over the concentration range of 7.7×10 -5 to 1.0×10 -2 mol L -1 with limit of detection of 5.3×10 -5 mol L -1 . The coated wire electrode has short response time ~ 10 s and it can be used in pH range of 4.0–7.0. The selectivity coefficients were determined in relation to several inorganic and organic species. The proposed sensor displayed useful analytical characteristics for the determination of pyrilamine in pharmaceutical preparation and biological fluids such as plasma and urine samples.
منابع مشابه
Determination of Mn2+ in Pharmaceutical Supplements by a Novel Coated Graphite Electrode Based on Zolpidem as a Neutral Ion Carrier
Manganese plays a key role in the health of human beings therefore, its determination is very important in medical fields. In this regards, a novel coated graphite electrode was constructed for determination of manganese (II) by using zolpidem as an ionophore, for the first time. The best performance was obtained of the membrane composition of PVC (32%), Potassium tetrakis (4-chlorophenyl) bora...
متن کاملDetermination of Magnesium (II) by a Coated Graphite Electrode Based on Risperidone as an Ionophore
In this research, a coated graphite electrode was constructed for determination of Mg2+ in pharmaceutical supplements. The designed sensor demonstrates an ideal Nernstian slope (30.1 mV. Decade-1) over a wide concentration range (1×10-6- 1×10-1 Mol L-1). The selectivity of the sensor was evaluated over 16 different cations by matched potential method and no serious interference was observed fro...
متن کاملNew Coated Graphite Potentiometric Sensor for Selective Determination of Copper (II) Ions
A highly selective copper (II) coated graphite sensor was prepared by 1,13-bis(8-quinolyl)- 1,4,7,10,13-pentaoxatridecane (kryptofix 5) as a supramolecule ionophore into plasticized polyvinyl chloride (PVC) membrane. The best response characteristic was observed using the membrane composition of PVC = 30.0 mg, dioctyl sebacate (DOS) = 63.5 mg, palmitic acid (PA) = 3.0 mg and kryptofix 5 = 3.5 m...
متن کاملDetermination of Cobalt(II) by a New PVC Membrane Coated Graphite Electrode Based on 6-chloro-11- azabenzo[a]phenothiazin-5-one as a neutral ion carrier
Cobalt has great biological effects on human beings and also other living organisms, hence its determination is very important. In this regard, a novel coated graphite electrode was designed for determination of Co2+ ions by exploiting 6-chloro-11- azabenzo[a]phenothiazin-5-one as a neutral ion carrier, for the first time. The foremost function was witnessed from the membrane composition of PVC...
متن کاملDevelopment of novel potentiometric sensors for determination of lidocaine hydrochloride in pharmaceutical preparations, serum and urine samples
This article is focused on the determination of lidocaine hydrochloride as a local anaesthetic drug. A potentiometric method based on modified screen-printed and modified carbon paste ion-selective electrodes was described for the determination of lidocaine hydrochloride in different pharmaceutical preparations. It was based on potentiometric titration of lidocaine hydrochloride using modified ...
متن کامل